Ontology highlight
ABSTRACT:
SUBMITTER: Gallez-Hawkins GM
PROVIDER: S-EPMC3478408 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Gallez-Hawkins Ghislaine M GM Li Xiuli X Franck Anne E AE Gendzekhadze Ketevan K Nakamura Ryotaro R Forman Stephen J SJ Senitzer David D Zaia John A JA
Human immunology 20120830 11
The killer cell Ig-like receptor (KIR)-MHC class I pathway is an integral part of natural killer cell immunity, and its role in host protection from both cancer and infection is important. In addition, we have shown elevated KIR2DS2 and 2DS4 expression in PBMCs of patients undergoing hematopoietic cell transplantation (HCT) [1]. Since all inhibitory KIR promoters are known to be heavily methylated, the question asked here is how and when KIR2DS2 and 2DS4 promoters had changed their methylation p ...[more]