Ontology highlight
ABSTRACT:
SUBMITTER: Chen L
PROVIDER: S-EPMC3478463 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Chen Limo L Aktas Bertal H BH Wang Yibo Y He Xiaoying X Sahoo Rupam R Zhang Nancy N Denoyelle Severine S Kabha Eihab E Yang Hongwei H Freedman Revital Yefidoff RY Supko Jeffrey G JG Chorev Michael M Wagner Gerhard G Halperin Jose A JA
Oncotarget 20120801 8
Translation initiation factors are over-expressed and/or activated in many human cancers and may contribute to their genesis and/or progression. Removal of physiologic restraints on translation initiation causes malignant transformation. Conversely, restoration of physiological restrains on translation initiation reverts malignant phenotypes. Here, we extensively characterize the anti-cancer activity of two small molecule inhibitors of translation initiation: #1181, which targets the eIF2∙GTP∙Me ...[more]