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Go hybrid: EM, crystallography, and beyond.

ABSTRACT: A mechanistic understanding of the molecular transactions that govern cellular function requires knowledge of the dynamic organization of the macromolecular machines involved in these processes. Structural biologists employ a variety of biophysical methods to study large macromolecular complexes, but no single technique is likely to provide a complete description of the structure-function relationship of all the constituent components. Since structural studies generally only provide snapshots of these dynamic machines as they accomplish their molecular functions, combining data from many methodologies is crucial to our understanding of molecular function.

SUBMITTER: Lander GC

PROVIDER: S-EPMC3478466 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature

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Go hybrid: EM, crystallography, and beyond.

Lander Gabriel C GC Saibil Helen R HR Nogales Eva E

Current opinion in structural biology 20120724 5

A mechanistic understanding of the molecular transactions that govern cellular function requires knowledge of the dynamic organization of the macromolecular machines involved in these processes. Structural biologists employ a variety of biophysical methods to study large macromolecular complexes, but no single technique is likely to provide a complete description of the structure-function relationship of all the constituent components. Since structural studies generally only provide snapshots of ...[more]

PMID: 22835744

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Cryo-EM Structure of the Open Human Ether-a-go-go-Related K<sup>+</sup> Channel hERG.

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