Cytotoxic mechanisms employed by mouse T cells to destroy pancreatic ?-cells.
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ABSTRACT:
SUBMITTER: Varanasi V
PROVIDER: S-EPMC3478530 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
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Cytotoxic mechanisms employed by mouse T cells to destroy pancreatic β-cells.
Varanasi Vineeth V Avanesyan Lia L Schumann Desiree M DM Chervonsky Alexander V AV
Diabetes 20120706 11
Several cytotoxic mechanisms have been attributed to T cells participating in β-cell death in type 1 diabetes. However, sensitivity of β-cells to these mechanisms in vitro and in vivo is likely to be different. Moreover, CD4⁺ and CD8⁺ T cells may use distinct mechanisms to cause β-cell demise that possibly involve activation of third-party cytotoxic cells. We used the transfer of genetically modified diabetogenic T cells into normal, mutant, and bone marrow chimeric recipients to test the contri ...[more]
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