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Total chemical synthesis of biologically active vascular endothelial growth factor.


ABSTRACT: Efficient access: the 204-residue covalent-dimer vascular endothelial growth factor with full mitogenic activity was prepared from three unprotected peptide segments by one-pot native chemical ligations. The covalent structure of the synthetic VEGF was confirmed by precise mass measurement, and the three-dimensional structure of the synthetic protein was determined by high-resolution X-ray crystallography.

SUBMITTER: Mandal K 

PROVIDER: S-EPMC3478761 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature

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Total chemical synthesis of biologically active vascular endothelial growth factor.

Mandal Kalyaneswar K   Kent Stephen B H SB  

Angewandte Chemie (International ed. in English) 20110708 35


Efficient access: the 204-residue covalent-dimer vascular endothelial growth factor with full mitogenic activity was prepared from three unprotected peptide segments by one-pot native chemical ligations. The covalent structure of the synthetic VEGF was confirmed by precise mass measurement, and the three-dimensional structure of the synthetic protein was determined by high-resolution X-ray crystallography. ...[more]

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