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Molecular cytogenetic characterization of undifferentiated embryonal sarcoma of the liver: a case report and literature review.

ABSTRACT: Undifferentiated embryonal sarcoma of the liver (UESL) represents a heterogeneous group of tumors derived from mesenchymal tissues. Earlier cytogenetic studies in limited cases demonstrated that UESL is associated with a recurrent translocation t(11;19)(q11;q13.3-q13.4) or add(19)(q13.4). In this report, we present our array comparative genomic hybridization (aCGH), fluorescence in situ hybridization (FISH) findings, and a missense mutation of TP53 gene by DNA sequencing in a 19-year-old patient with UESL. The data were compared to laboratory findings reported by previous studies.

SUBMITTER: Hu X

PROVIDER: S-EPMC3478990 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature

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Molecular cytogenetic characterization of undifferentiated embryonal sarcoma of the liver: a case report and literature review.

Hu Xiaoxia X Chen Haiying H Jin Meishan M Wang Xianfu X Lee Jiyun J Xu Weihong W Zhang Rui R Li Shibo S Niu Junqi J

Molecular cytogenetics 20120503 1

Undifferentiated embryonal sarcoma of the liver (UESL) represents a heterogeneous group of tumors derived from mesenchymal tissues. Earlier cytogenetic studies in limited cases demonstrated that UESL is associated with a recurrent translocation t(11;19)(q11;q13.3-q13.4) or add(19)(q13.4). In this report, we present our array comparative genomic hybridization (aCGH), fluorescence in situ hybridization (FISH) findings, and a missense mutation of TP53 gene by DNA sequencing in a 19-year-old patient ...[more]

PMID: 22551002

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