Ontology highlight
ABSTRACT:
SUBMITTER: Hoxha E
PROVIDER: S-EPMC3479375 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Hoxha Eneda E Lambers Erin E Xie Hehuang H De Andrade Alexandre A Krishnamurthy Prasanna P Wasserstrom John A JA Ramirez Veronica V Thal Melissa M Verma Suresh K SK Soares Marcelo B MB Kishore Raj R
Stem cells (Dayton, Ohio) 20121101 11
Epigenetic and chromatin modifications play particularly important roles in embryonic and induced pluripotent stem cells (ESCs and iPSCs) allowing for the cells to both differentiate and dedifferentiate back to a pluripotent state. We analyzed how the loss of a key chromatin-modifying enzyme, histone deacetylase 1 (HDAC1), affects early and cardiovascular differentiation of both ESCs and iPSCs. We also investigated potential differences between these two cell types when differentiation is induce ...[more]