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Nanostructured thin film polymer devices for constant-rate protein delivery.

ABSTRACT: Herein long-term delivery of proteins from biodegradable thin film devices is demonstrated, where a nanostructured polymer membrane controls release. Protein was sealed between two poly(caprolactone) films, which generated the thin film devices. Protein release for 210 days was shown in vitro, and stable activity was established through 70 days with a model protein. These thin film devices present a promising delivery platform for biologic therapeutics, particularly for application in constrained spaces.

SUBMITTER: Bernards DA

PROVIDER: S-EPMC3480309 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature

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Nanostructured thin film polymer devices for constant-rate protein delivery.

Bernards Daniel A DA Lance Kevin D KD Ciaccio Natalie A NA Desai Tejal A TA

Nano letters 20120919 10

Herein long-term delivery of proteins from biodegradable thin film devices is demonstrated, where a nanostructured polymer membrane controls release. Protein was sealed between two poly(caprolactone) films, which generated the thin film devices. Protein release for 210 days was shown in vitro, and stable activity was established through 70 days with a model protein. These thin film devices present a promising delivery platform for biologic therapeutics, particularly for application in constraine ...[more]

PMID: 22985294

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