Ontology highlight
ABSTRACT:
SUBMITTER: Lanaspa MA
PROVIDER: S-EPMC3480441 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Lanaspa Miguel A MA Sanchez-Lozada Laura G LG Cicerchi Christina C Li Nanxing N Roncal-Jimenez Carlos A CA Ishimoto Takuji T Le Myphuong M Garcia Gabriela E GE Thomas Jeffrey B JB Rivard Christopher J CJ Andres-Hernando Ana A Hunter Brandi B Schreiner George G Rodriguez-Iturbe Bernardo B Sautin Yuri Y YY Johnson Richard J RJ
PloS one 20121024 10
Excessive dietary fructose intake may have an important role in the current epidemics of fatty liver, obesity and diabetes as its intake parallels the development of these syndromes and because it can induce features of metabolic syndrome. The effects of fructose to induce fatty liver, hypertriglyceridemia and insulin resistance, however, vary dramatically among individuals. The first step in fructose metabolism is mediated by fructokinase (KHK), which phosphorylates fructose to fructose-1-phosp ...[more]