Ontology highlight
ABSTRACT:
SUBMITTER: Hassler MR
PROVIDER: S-EPMC3480637 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Hassler Melanie R MR Klisaroska Aleksandra A Kollmann Karoline K Steiner Irene I Bilban Martin M Schiefer Ana-Iris AI Sexl Veronika V Egger Gerda G
Biochimie 20120609 11
DNA methylation is an epigenetic mechanism establishing long-term gene silencing during development and cell commitment, which is maintained in subsequent cell generations. Aberrant DNA methylation is found at gene promoters in most cancers and can lead to silencing of tumor suppressor genes. The DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine (5-aza-CdR) is able to reactivate genes silenced by DNA methylation and has been shown to be a very potent epigenetic drug in several hematological ...[more]