Ontology highlight
ABSTRACT:
SUBMITTER: Mostardinha P
PROVIDER: S-EPMC3480656 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Mostardinha P P de Abreu F Vistulo FV
Scientific reports 20121025
It is still unclear whether the adaptive immune system can perform accurate self-nonself discrimination and what could influence its performance. Starting from simple cellular interaction rules we show that it is possible to achieve perfect self-nonself discrimination in a consistent framework provided positive and negative selection operate during repertoire education, and costimulation and anergy are also considered during T cell activation. In this theory T cell receptors diversity is require ...[more]