Chromosome 1p13 genetic variants antagonize the risk of myocardial infarction associated with high ApoB serum levels.

ABSTRACT: BACKGROUND: Genetic variation at 1p13 modulates serum lipid levels and the risk of coronary heart disease through the regulation of serum lipid levels. Here we investigate if the interaction between genetic variants at 1p13 and serum lipid levels affects the risk of non-fatal myocardial infarction (MI) in the Stockholm Heart Epidemiology Program (SHEEP), a large population based case control study. METHODS: In the present study only non fatal MI cases (n?=?1213, men/women: 852/361) and controls (n?=?1516, men/women =1054/507) matched by age, sex and residential area, were included. Three SNPs 12740374?G/T, rs599839A/G and rs646776T/C mapping at 1p13 were analysed for association with serum lipid levels and the risk of MI by a weighted least square regression and logistic regression analyses, respectively. To analyse the effect of the interaction between genetic variants and serum lipid levels on the risk of MI, we applied the biological model of interaction that estimates the difference in risk, expressed as OR (95%CI), observed in the presence and in the absence of both exposures. One derived measure is the Synergy index (S) and 95%CI, where S?>?1 indicates synergy and S?

SUBMITTER: Gigante B 

PROVIDER: S-EPMC3480949 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature