Ontology highlight
ABSTRACT:
SUBMITTER: Baltan S
PROVIDER: S-EPMC3481173 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Journal of neurochemistry 20121101
Aging increases the vulnerability of aging white matter to ischemic injury. Histone deacetylase (HDAC) inhibitors preserve young adult white matter structure and function during ischemia by conserving ATP and reducing excitotoxicity. In isolated optic nerve from 12-month-old mice, deprived of oxygen and glucose, we show that pan- and Class I-specific HDAC inhibitors promote functional recovery of axons. This protection correlates with preservation of axonal mitochondria. The cellular expression ...[more]