Ontology highlight
ABSTRACT:
SUBMITTER: McAteer MA
PROVIDER: S-EPMC3481783 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
McAteer Martina A MA Schneider Jurgen E JE Ali Ziad A ZA Warrick Nicholas N Bursill Christina A CA von zur Muhlen Constantin C Greaves David R DR Neubauer Stefan S Channon Keith M KM Choudhury Robin P RP
Arteriosclerosis, thrombosis, and vascular biology 20071025 1
<h4>Objective</h4>Microparticles of iron oxide (MPIO) distort magnetic field creating marked contrast effects far exceeding their physical size. We hypothesized that antibody-conjugated MPIO would enable magnetic resonance imaging (MRI) of endothelial cell adhesion molecules in mouse atherosclerosis.<h4>Methods and results</h4>MPIO (4.5 microm) were conjugated to monoclonal antibodies against vascular cell adhesion molecule-1 (VCAM-MPIO) or P-selectin (P-selectin-MPIO). In vitro, VCAM-MPIO bound ...[more]