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Descriptive epidemiology of non-syndromic complete atrioventricular canal defects.


ABSTRACT: Complete atrioventricular canal defects (CAVC) are a common heart defect, but few epidemiologic studies have evaluated non-syndromic CAVC. Risk factors for non-syndromic CAVC have not been well established.To assess the relationship between risk for non-syndromic CAVC in offspring and several sociodemographic and reproductive parental factors, including maternal diabetes and obesity, we conducted Poisson regression analyses, using data ascertained through the Texas Birth Defects Registry, a large, population-based birth defects registry. Data were evaluated for 563 non-syndromic cases with CAVC.Significant associations were observed between non-syndromic CAVC in offspring and maternal pregestational diabetes (adjusted prevalence ratio (aPR) 6.74; 95% confidence interval (CI) 3.67, 12.37), gestational diabetes (aPR 1.69; 95% CI 1.03, 2.79) and obesity (aPR 1.69; 95% CI 1.24, 2.30).?Our findings add non-syndromic CAVC to the growing list of birth defects that appear to be associated with maternal diabetes and obesity.

SUBMITTER: Agopian AJ 

PROVIDER: S-EPMC3482101 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature

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Descriptive epidemiology of non-syndromic complete atrioventricular canal defects.

Agopian A J AJ   Moulik Mousumi M   Gupta-Malhotra Monesha M   Marengo Lisa K LK   Mitchell Laura E LE  

Paediatric and perinatal epidemiology 20120924 6


<h4>Background</h4>Complete atrioventricular canal defects (CAVC) are a common heart defect, but few epidemiologic studies have evaluated non-syndromic CAVC. Risk factors for non-syndromic CAVC have not been well established.<h4>Methods</h4>To assess the relationship between risk for non-syndromic CAVC in offspring and several sociodemographic and reproductive parental factors, including maternal diabetes and obesity, we conducted Poisson regression analyses, using data ascertained through the T  ...[more]

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