Ontology highlight
ABSTRACT:
SUBMITTER: Li W
PROVIDER: S-EPMC3482194 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Li Wencheng W Yeh Hsiang-Jui HJ Shankarling Ganesh S GS Ji Zhe Z Tian Bin B MacDonald Clinton C CC MacDonald Clinton C CC
PloS one 20121026 10
The τCstF-64 polyadenylation protein (gene symbol Cstf2t) is a testis-expressed orthologue of CstF-64. Mice in which Cstf2t was knocked out had a phenotype that was only detected in meiotic and postmeiotic male germ cells, giving us the opportunity to examine CstF-64 function in an isolated developmental system. We performed massively parallel clonally amplified sequencing of cDNAs from testes of wild type and Cstf2t(-/-) mice. These results revealed that loss of τCstF-64 resulted in large-scale ...[more]