Ontology highlight
ABSTRACT:
SUBMITTER: Ghosh AK
PROVIDER: S-EPMC3482479 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Ghosh Arun K AK Anderson David D DD
Organic letters 20120906 18
An enantioselective and convergent total synthesis of pladienolide B (1) is described. Pladienolide B binds to the SF3b complex of a spliceosome and inhibits mRNA splicing activity. The synthesis features an epoxide opening reaction, an asymmetric reduction of a β-keto ester, and a cross metathesis strategy for the side chain synthesis. ...[more]