Thioredoxin and thioredoxin-interacting protein as prognostic markers for gastric cancer recurrence.

ABSTRACT:

Aim

To evaluate the potential of thioredoxin (TXN) and thioredoxin-interacting protein (TXNIP) expression as biomarkers for predicting gastric cancer recurrence.

Methods

TXN and TXNIP expression levels were acquired from gene expression microarray data for 65 human gastric cancer tissues. We determined whether each gene expression level was associated with cancer recurrence and investigated the relationship between the two genes. For validation, the expression levels of TXN and TXNIP were measured by quantitative real-time reverse transcription polymerase chain reaction in 68 independent stage III gastric cancer patients. The correlation between gene expression and cancer prognosis was evaluated. Immunohistochemical staining was performed to investigate the protein expressio

SUBMITTER: Lim JY 

PROVIDER: S-EPMC3482645 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature