Activation of liver X receptor inhibits osteopontin and ameliorates diabetic nephropathy.
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ABSTRACT:
SUBMITTER: Tachibana H
PROVIDER: S-EPMC3482729 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
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Activation of liver X receptor inhibits osteopontin and ameliorates diabetic nephropathy.
Tachibana Hiromi H Ogawa Daisuke D Matsushita Yuichi Y Bruemmer Dennis D Wada Jun J Teshigawara Sanae S Eguchi Jun J Sato-Horiguchi Chikage C Uchida Haruhito Adam HA Shikata Kenichi K Makino Hirofumi H
Journal of the American Society of Nephrology : JASN 20121018 11
Osteopontin is a proinflammatory cytokine and monocyte chemoattractant implicated in the pathogenesis of diabetic nephropathy. Synthetic agonists for liver X receptors (LXRs) suppress the expression of proinflammatory genes, including osteopontin, but whether LXR activation modulates diabetic nephropathy is unknown. We administered the LXR agonist T0901317 to mice with streptozotocin-induced diabetes and evaluated its effects on diabetic nephropathy. The LXR agonist decreased urinary albumin exc ...[more]
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