Associations between ABCC2 polymorphisms and cisplatin disposition and efficacy.
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ABSTRACT:
SUBMITTER: Sprowl JA
PROVIDER: S-EPMC3482956 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Publications
Associations between ABCC2 polymorphisms and cisplatin disposition and efficacy.
Sprowl J A JA Gregorc V V Lazzari C C Mathijssen R H RH Loos W J WJ Sparreboom A A
Clinical pharmacology and therapeutics 20120601 6
ABCC2 (MRP2, cMOAT) expression has been implicated in cisplatin resistance in vitro. In mice, cisplatin disposition and toxicity were unaffected by Abcc2 knockout (Abcc2−/−). Moreover, in cancer patients (n = 237), cisplatin pharmacokinetics (P > 0.12) and efficacy (P > 0.41) were not associated with seven of the single-nucleotide polymorphisms (SNPs) in ABCC2. These SNPs were also not correlated with ABCC2 expression in the NCI60 panel (P > 0.26) or with cisplatin-induced cytotoxicity (P = 0.21 ...[more]
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