Ontology highlight
ABSTRACT:
SUBMITTER: Jayasena CS
PROVIDER: S-EPMC3483135 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
The Journal of cell biology 20121022 3
Cranial neural crest cells form much of the facial skeleton, and abnormalities in their development lead to severe birth defects. In a novel zebrafish protein trap screen, we identified an RNA-binding protein, Rbms3, that is transiently expressed in the cytoplasm of condensing neural crest cells within the pharyngeal arches. Morphants for rbms3 displayed reduced proliferation of prechondrogenic crest and significantly altered expression for chondrogenic/osteogenic lineage markers. This phenotype ...[more]