Assessing predictors of changes in protein stability upon mutation using self-consistency.
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ABSTRACT:
SUBMITTER: Thiltgen G
PROVIDER: S-EPMC3483175 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Assessing predictors of changes in protein stability upon mutation using self-consistency.
Thiltgen Grant G Goldstein Richard A RA
PloS one 20121029 10
The ability to predict the effect of mutations on protein stability is important for a wide range of tasks, from protein engineering to assessing the impact of SNPs to understanding basic protein biophysics. A number of methods have been developed that make these predictions, but assessing the accuracy of these tools is difficult given the limitations and inconsistencies of the experimental data. We evaluate four different methods based on the ability of these methods to generate consistent resu ...[more]
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