Ontology highlight
ABSTRACT:
SUBMITTER: Kasumu AW
PROVIDER: S-EPMC3483567 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Chemistry & biology 20121001 10
Spinocerebellar ataxia type 2 (SCA2) is a neurodegenerative disorder caused by a polyglutamine expansion within the Ataxin-2 (Atxn2) protein. Purkinje cells (PC) of the cerebellum fire irregularly and eventually die in SCA2. We show here that the type 2 small conductance calcium-activated potassium channel (SK2) play a key role in control of normal PC activity. Using cerebellar slices from transgenic SCA2 mice we demonstrate that SK channel modulators restore regular pacemaker activity of SCA2 P ...[more]