Ontology highlight
ABSTRACT:
SUBMITTER: Gombos A
PROVIDER: S-EPMC3484277 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Gombos Andrea A Metzger-Filho Otto O Dal Lago Lissandra L Awada-Hussein Ahmad A
Investigational new drugs 20120314 6
Insulin like growth factor receptor (IGF-1R) targeting became one of the most investigated areas in anticancer drug development during the last decade. Strategies aiming to block IGF-1R activity include monoclonal antibodies, tyrosine kinase inhibitors and anti-ligands antibodies. Initial enthusiasm quickly encountered challenges. Unfortunately the validation of the efficacy of IGF-1R targeted agents in large clinical trials failed, however anecdotal single agent activity was seen in early studi ...[more]