Ontology highlight
ABSTRACT:
SUBMITTER: Zhang L
PROVIDER: S-EPMC3485208 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Zhang Ling L Gao Guanghui G Li Xuefei X Ren Shengxiang S Li Aiwu A Xu Jianfang J Zhang Jie J Zhou Caicun C
PloS one 20121031 10
New therapeutic approaches are being developed based on the findings that several genetic abnormalities underlying non-small-cell lung cancer (NSCLC) could influence chemosensitivity. In this study, we assessed whether polymorphisms in genes of nucleotide excision repair (NER) pathway, including ERCC5, ERCC6, MMS19L, CCNH, XPC, RRM1, can affect the tolerability of platinum-based chemotherapy in NSCLC patients. We used AllGloTM probe to assess genotyping and polymorphisms in 388 stage IIIB and IV ...[more]