Short and long term measures of anxiety exhibit opposite results.
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ABSTRACT:
SUBMITTER: Fonio E
PROVIDER: S-EPMC3485251 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Short and long term measures of anxiety exhibit opposite results.
Fonio Ehud E Benjamini Yoav Y Golani Ilan I
PloS one 20121031 10
Animal models of human diseases of the central nervous system, generalized anxiety disorder included, are essential for the study of the brain-behavior interface and obligatory for drug development; yet, these models fail to yield new insights and efficacious drugs. By increasing testing duration hundredfold and arena size tenfold, and comparing the behavior of the common animal model to that of wild mice, we raise concerns that chronic anxiety might have been measured at the wrong time, for the ...[more]
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