Ontology highlight
ABSTRACT:
SUBMITTER: Subramanian T
PROVIDER: S-EPMC3485679 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Synlett : accounts and rapid communications in synthetic organic chemistry 20121001 17
A solid-phase three-component Huisgen reaction has been used to generate polar farnesol and farnesyl diphosphate analogues. The Cu(I)-catalyzed 1,3-cycloadditions of various azides with solid supported (E)-3-methylhept-2-en-6-yn-1-ol provided only the 1,4-disubstituted 1,2,3-triazole regioisomers. The organic azides were generated in situ to minimize handling of potentially explosive azides. We have employed this powerful 'click chemistry' to make farnesol analogues where both β- and γ-isoprenes ...[more]