Enhancement of acetic acid tolerance in Saccharomyces cerevisiae by overexpression of the HAA1 gene, encoding a transcriptional activator.
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ABSTRACT:
SUBMITTER: Tanaka K
PROVIDER: S-EPMC3485965 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
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Enhancement of acetic acid tolerance in Saccharomyces cerevisiae by overexpression of the HAA1 gene, encoding a transcriptional activator.
Tanaka Koichi K Ishii Yukari Y Ogawa Jun J Shima Jun J
Applied and environmental microbiology 20120907 22
Haa1 is a transcriptional activator required for Saccharomyces cerevisiae adaptation to weak acids. Here we show that the constitutive HAA1-overexpressing strain acquired a higher level of acetic acid tolerance. Under conditions of acetic acid stress, the intracellular level of acetic acid was significantly lower in HAA1-overexpressing cells than in the wild-type cells. ...[more]
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