Ontology highlight
ABSTRACT:
SUBMITTER: Zhang AP
PROVIDER: S-EPMC3485981 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Zhang Adrianna P P AP Abelson Dafna M DM Bornholdt Zachary A ZA Liu Tong T Woods Virgil L VL Saphire Erica Ollmann EO
Virulence 20120815 5
Suppression during the early phases of the immune system often correlates directly with a fatal outcome for the host. The ebolaviruses, some of the most lethal viruses known, appear to cripple initial stages of the host defense network via multiple distinct paths. Two of the eight viral proteins are critical for immunosuppression. One of these proteins is VP35, which binds double-stranded RNA and antagonizes several antiviral signaling pathways. The other protein is VP24, which binds transporter ...[more]