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Wnt antagonist SFRP1 functions as a secreted mediator of senescence.


ABSTRACT: Cellular senescence has emerged as a critical tumor suppressive mechanism in recent years, but relatively little is known about how senescence occurs. Here, we report that secreted Frizzled-related protein 1 (SFRP1), a secreted antagonist of Wnt signaling, is oversecreted upon cellular senescence caused by DNA damage or oxidative stress. SFRP1 is necessary for stress-induced senescence caused by these factors and is sufficient for the induction of senescence phenotypes. We present evidence suggesting that SFRP1 functions as a secreted mediator of senescence through inhibition of Wnt signaling and activation of the retinoblastoma (Rb) pathway and that cancer-associated SFRP1 mutants are defective for senescence induction.

SUBMITTER: Elzi DJ 

PROVIDER: S-EPMC3486147 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature

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Wnt antagonist SFRP1 functions as a secreted mediator of senescence.

Elzi David J DJ   Song Meihua M   Hakala Kevin K   Weintraub Susan T ST   Shiio Yuzuru Y  

Molecular and cellular biology 20120827 21


Cellular senescence has emerged as a critical tumor suppressive mechanism in recent years, but relatively little is known about how senescence occurs. Here, we report that secreted Frizzled-related protein 1 (SFRP1), a secreted antagonist of Wnt signaling, is oversecreted upon cellular senescence caused by DNA damage or oxidative stress. SFRP1 is necessary for stress-induced senescence caused by these factors and is sufficient for the induction of senescence phenotypes. We present evidence sugge  ...[more]

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