Wnt antagonist SFRP1 functions as a secreted mediator of senescence.
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ABSTRACT:
SUBMITTER: Elzi DJ
PROVIDER: S-EPMC3486147 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Publications
Wnt antagonist SFRP1 functions as a secreted mediator of senescence.
Elzi David J DJ Song Meihua M Hakala Kevin K Weintraub Susan T ST Shiio Yuzuru Y
Molecular and cellular biology 20120827 21
Cellular senescence has emerged as a critical tumor suppressive mechanism in recent years, but relatively little is known about how senescence occurs. Here, we report that secreted Frizzled-related protein 1 (SFRP1), a secreted antagonist of Wnt signaling, is oversecreted upon cellular senescence caused by DNA damage or oxidative stress. SFRP1 is necessary for stress-induced senescence caused by these factors and is sufficient for the induction of senescence phenotypes. We present evidence sugge ...[more]
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