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Surface Modification of Poly(amidoamine) (PAMAM) Dendrimer as Antimicrobial Agents.

ABSTRACT: Poly(amidoamine) (PAMAM) (G3) dendrimer was modified into quaternary ammonium salts using tertiary amines with different chain lengths: dimethyldodecyl amine, dimethylhexyl amine, and dimethylbutyl amine using an efficient synthetic route. The antimicrobial activity of these dendrimer ammonium salts against Staphylococcus and E-coli bacteria was examined using the disc diffusion method. It was found that quaternary ammonium salt prepared with the dimethyldodecyl amine exhibits antimicrobial efficacy against Staphalococus and E.coli bacteria.

SUBMITTER: Charles S

PROVIDER: S-EPMC3486433 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature

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Surface Modification of Poly(amidoamine) (PAMAM) Dendrimer as Antimicrobial Agents.

Charles Shakira S Vasanthan Nadarajah N Kwon Dong D Sekosan Gabriela G Ghosh Subhas S

Tetrahedron letters 20120928 49

Poly(amidoamine) (PAMAM) (G3) dendrimer was modified into quaternary ammonium salts using tertiary amines with different chain lengths: dimethyldodecyl amine, dimethylhexyl amine, and dimethylbutyl amine using an efficient synthetic route. The antimicrobial activity of these dendrimer ammonium salts against Staphylococcus and E-coli bacteria was examined using the disc diffusion method. It was found that quaternary ammonium salt prepared with the dimethyldodecyl amine exhibits antimicrobial effi ...[more]

PMID: 23125468

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