Zinc finger antiviral protein inhibits murine gammaherpesvirus 68 M2 expression and regulates viral latency in cultured cells.
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ABSTRACT:
SUBMITTER: Xuan Y
PROVIDER: S-EPMC3486457 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Publications
Zinc finger antiviral protein inhibits murine gammaherpesvirus 68 M2 expression and regulates viral latency in cultured cells.
Xuan Yifang Y Liu Ling L Shen Sheng S Deng Hongyu H Gao Guangxia G
Journal of virology 20120905 22
Zinc finger antiviral protein (ZAP) is a host factor that specifically inhibits the replication of certain viruses by binding to specific viral mRNAs and repressing mRNA expression. Here we report that ZAP inhibits expression of murine gammaherpesvirus 68 (MHV-68) M2, which plays important roles in establishment and maintenance of viral latency. Downregulation of endogenous ZAP in cells harboring latent MHV-68 promoted lytic replication of the virus. These results suggest that ZAP inhibits M2 ex ...[more]
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