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Complete genome sequence of Central Africa human T-cell lymphotropic virus subtype 1b.

ABSTRACT: Human T-lymphotropic virus type 1 (HTLV-1) has a global spread, and it is estimated that around 20 million persons are infected. Seven major genetic subtypes are recognized. However, there are complete genomes only from the HTLV-1a (cosmopolitan) and HTLV-1c (Melanesian) subtypes. Here, the first full-length genome of an HTLV-1b strain, a subtype so far restricted to Central African countries, is revealed. The genome size of HTLV-1b SF26, a strain isolated in Brazil, was determined to be 8,267 bp. The genomic analysis showed that all characteristic regions and genes of a prototypic HTLV-1 virus are conserved. This genome can provide information for further studies on the evolutionary history and pathogenic potential of this human oncovirus.

SUBMITTER: Zanella L

PROVIDER: S-EPMC3486502 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature

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Complete genome sequence of Central Africa human T-cell lymphotropic virus subtype 1b.

Zanella Louise L Otsuki Koko K Marin Michel Abanto MA Bendet Izidro I Vicente Ana Carolina AC

Journal of virology 20121101 22

Human T-lymphotropic virus type 1 (HTLV-1) has a global spread, and it is estimated that around 20 million persons are infected. Seven major genetic subtypes are recognized. However, there are complete genomes only from the HTLV-1a (cosmopolitan) and HTLV-1c (Melanesian) subtypes. Here, the first full-length genome of an HTLV-1b strain, a subtype so far restricted to Central African countries, is revealed. The genome size of HTLV-1b SF26, a strain isolated in Brazil, was determined to be 8,267 b ...[more]

PMID: 23087114

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