Ontology highlight
ABSTRACT:
SUBMITTER: Lou Y
PROVIDER: S-EPMC3486891 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Lou Yuefen Y Lu Xiaojiong X Dang Xitong X
Gene regulation and systems biology 20121029
L-selectin plays important roles in lymphocyte homing and leukocyte rolling. Mounting evidence shows that it is involved in many disease entities including diabetes, ischemia/reperfusion injuries, inflammatory diseases, and tumor metastasis. Regulation of L-selectin at protein level has been well characterized. However, the regulation of human L-selectin transcription remains largely unknown. To address transcriptional regulation of L-selectin, we cloned 1088 bp 5' of the start codon ATG. Lucife ...[more]