Ontology highlight
ABSTRACT:
SUBMITTER: Petzer AL
PROVIDER: S-EPMC3487557 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Petzer Andreas L AL Fong Dominic D Lion Thomas T Dyagil Irina I Masliak Zvenyslava Z Bogdanovic Andrija A Griskevicius Laimonas L Lejniece Sandra S Goranov Stefan S Gercheva Liana L Stojanovic Aleksandar A Peytchev Dontcho D Tzvetkov Nikolay N Griniute Rasa R Stanchev Atanas A Grubinger Thomas T Kwakkelstein Marthin M Schuld Peter P Gastl Guenther G Wolf Dominik D
Haematologica 20120417 10
<h4>Background</h4>Previous data suggest that the response of chronic myeloid leukemia cells to imatinib is dose-dependent. The potential benefit of initial dose intensification of imatinib in pre-treated patients with chronic phase chronic myeloid leukemia remains unknown.<h4>Design and methods</h4>Two hundred and twenty-seven pre-treated patients with chronic myeloid leukemia in chronic phase were randomly assigned to continuous treatment with a standard dose of imatinib (400 mg/day; n=113) or ...[more]