Ontology highlight
ABSTRACT:
SUBMITTER: Wang K
PROVIDER: S-EPMC3488067 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20120913 45
Macroautophagy (hereafter autophagy) is a degradative cellular pathway that protects eukaryotic cells from stress, starvation, and microbial infection. This process must be tightly controlled because too little or too much autophagy can be deleterious to cellular physiology. The phosphatidylinositol (PtdIns) 3-kinase Vps34 is a lipid kinase that regulates autophagy, but the role of other PtdIns kinases has not been examined. Here we demonstrate a role for PtdIns 4-kinases and PtdIns4P 5-kinases ...[more]