Ontology highlight
ABSTRACT:
SUBMITTER: North JA
PROVIDER: S-EPMC3488218 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Nucleic acids research 20120910 20
Eukaryotic genomes are repetitively wrapped into nucleosomes that then regulate access of transcription and DNA repair complexes to DNA. The mechanisms that regulate extrinsic protein interactions within nucleosomes are unresolved. We demonstrate that modulation of the nucleosome unwrapping rate regulates protein binding within nucleosomes. Histone H3 acetyl-lysine 56 [H3(K56ac)] and DNA sequence within the nucleosome entry-exit region additively influence nucleosomal DNA accessibility by increa ...[more]