Ontology highlight
ABSTRACT:
SUBMITTER: Peacock-Villada A
PROVIDER: S-EPMC3488227 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Peacock-Villada Alexandra A Yang Darren D Danilowicz Claudia C Feinstein Efraim E Pollock Nolan N McShan Sarah S Coljee Vincent V Prentiss Mara M
Nucleic acids research 20120831 20
RecA-family proteins mediate homologous recombination and recombinational DNA repair through homology search and strand exchange. Initially, the protein forms a filament with the incoming single-stranded DNA (ssDNA) bound in site I. The RecA-ssDNA filament then binds double-stranded DNA (dsDNA) in site II. Non-homologous dsDNA rapidly unbinds, whereas homologous dsDNA undergoes strand exchange yielding heteroduplex dsDNA in site I and the leftover outgoing strand in site II. We show that applyin ...[more]