Ontology highlight
ABSTRACT:
SUBMITTER: Garcia J
PROVIDER: S-EPMC3488262 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
García Jesús J Cordeiro Tiago N TN Cordeiro Tiago N TN Prieto María J MJ Pons Miquel M
Nucleic acids research 20120910 20
Ler is a DNA-binding, oligomerizable protein that regulates pathogenicity islands in enterohemorrhagic and enteropathogenic Escherichia coli strains. Ler counteracts the transcriptional silencing effect of H-NS, another oligomerizable nucleoid-associated protein. We studied the oligomerization of Ler in the absence and presence of DNA by atomic force microscopy. Ler forms compact particles with a multimodal size distribution corresponding to multiples of 3-5 units of Ler. DNA wraps around Ler pa ...[more]