Ontology highlight
ABSTRACT:
SUBMITTER: Ershova AS
PROVIDER: S-EPMC3488263 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Ershova Anna S AS Karyagina Anna S AS Vasiliev Mikhail O MO Lyashchuk Alexander M AM Lunin Vladimir G VG Spirin Sergey A SA Alexeevski Andrei V AV
Nucleic acids research 20120910 20
Prokaryotic restriction-modification (R-M) systems defend the host cell from the invasion of a foreign DNA. They comprise two enzymatic activities: specific DNA cleavage activity and DNA methylation activity preventing cleavage. Typically, these activities are provided by two separate enzymes: a DNA methyltransferase (MTase) and a restriction endonuclease (RE). In the absence of a corresponding MTase, an RE of Type II R-M system is highly toxic for the cell. Genes of the R-M system are linked in ...[more]