Dataset Information

Childhood adversities and adult-onset asthma: a cohort study.

ABSTRACT:

Objectives

Childhood adversities may be important determinants of later illnesses and poor health behaviour. However, large-scale prospective studies on the associations between childhood adversities and the onset of asthma in adulthood are lacking.

Design

Prospective cohort study with 7-year follow-up.

Setting

Nationally representative study. Data were collected from the Health and Social Support (HeSSup) survey and national registers.

Participants

The participants represent the Finnish population from the following age groups: 20-24, 30-34, 40-44, and 50-54 years at baseline in 1998 (24 057 survey participants formed the final cohort of this study). The occurrence of childhood adversities was assessed at baseline with a six-item survey scale. The analyses were adjusted for sociodemographic characteristics, behavioural health risks and common mental disorders.

Primary and secondary outcomes

The survey data were linked to data from national health registers on incident asthma during a 7-year follow-up to define new-onset asthma cases with verified diagnoses.

Results

A total of 12 126 (59%) participants reported that they encountered a childhood adversity. Of them 3677 (18% of all) endured three to six adversities. During a follow-up of 7 years, 593 (2.9%) participants were diagnosed with incident asthma. Those who reported three or more childhood adversities had a 1.6-fold (95% CI 1.31 to 2.01) greater risk of asthma compared to those without childhood adversities. This hazard attenuated but remained statistically significant after adjustment for conventional risk factors (HR 1.33; 95% CI 1.06 to 1.67).

Conclusions

Adults who report having encountered adversities in childhood may have an increased risk of developing asthma.

SUBMITTER: Korkeila J

PROVIDER: S-EPMC3488721 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Childhood adversities and adult-onset asthma: a cohort study.

Korkeila Jyrki J Lietzen Raija R Sillanmäki Lauri H LH Rautava Päivi P Korkeila Katariina K Kivimäki Mika M Koskenvuo Markku M Vahtera Jussi J

BMJ open 20121014 5

<h4>Objectives</h4>Childhood adversities may be important determinants of later illnesses and poor health behaviour. However, large-scale prospective studies on the associations between childhood adversities and the onset of asthma in adulthood are lacking.<h4>Design</h4>Prospective cohort study with 7-year follow-up.<h4>Setting</h4>Nationally representative study. Data were collected from the Health and Social Support (HeSSup) survey and national registers.<h4>Participants</h4>The participants ...[more]

PMID: 23069774

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Dataset Information

Childhood adversities and adult-onset asthma: a cohort study.

Objectives

Design

Setting

Participants

Primary and secondary outcomes

Results

Conclusions

Publications

Childhood adversities and adult-onset asthma: a cohort study.

Similar Datasets

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