Ontology highlight
ABSTRACT:
SUBMITTER: Lattanzi W
PROVIDER: S-EPMC3488859 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Lattanzi W W Parrilla C C Fetoni A A Logroscino G G Straface G G Pecorini G G Stigliano E E Tampieri A A Bedini R R Pecci R R Michetti F F Gambotto A A Robbins P D PD Pola E E
Gene therapy 20080717 19
Local gene transfer of the human Lim mineralization protein (LMP), a novel intracellular positive regulator of the osteoblast differentiation program, can induce efficient bone formation in rodents. To develop a clinically relevant gene therapy approach to facilitate bone healing, we have used primary dermal fibroblasts transduced ex vivo with Ad.LMP-3 and seeded on a hydroxyapatite/collagen matrix prior to autologous implantation. Here, we demonstrate that genetically modified autologous dermal ...[more]