Ontology highlight
ABSTRACT:
SUBMITTER: Jacobine AM
PROVIDER: S-EPMC3489501 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Jacobine Alexander M AM Puchlopek Angela L A AL Zercher Charles K CK Briggs Jon B JB Jasinski Jerry P JP Butcher Raymond J RJ
Tetrahedron 20120717 38
A zinc carbenoid-initiated chain extension reaction provides access to an organometallic intermediate, which can be used to capture activated imines. Deprotection of the nitrogen and reduction provides access to racemic derivatives of β-proline. The relative stereochemistry of the β-proline can be controlled through use of different activating groups on the imine nitrogen. ...[more]