Boosting antibody-dependant cellular cytotoxicity against tumor cells with a CD137 stimulatory antibody.
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ABSTRACT:
SUBMITTER: Houot R
PROVIDER: S-EPMC3489758 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
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Boosting antibody-dependant cellular cytotoxicity against tumor cells with a CD137 stimulatory antibody.
Houot Roch R Kohrt Holbrook H Levy Ron R
Oncoimmunology 20120901 6
Monoclonal antibodies (mAb) induce tumor regression through antibody-dependant cellular cytotoxicity (ADCC). We recently showed that an agonistic anti-CD137 mAb stimulates natural killer (NK) cells which have been activated by a tumor-specific mAb, resulting in increased ADCC against cancer cells. ...[more]
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