Combined targeted therapy and immunotherapy in the treatment of advanced melanoma.
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ABSTRACT:
SUBMITTER: Wilmott JS
PROVIDER: S-EPMC3489773 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Publications
Combined targeted therapy and immunotherapy in the treatment of advanced melanoma.
Wilmott James S JS Scolyer Richard A RA Long Georgina V GV Hersey Peter P
Oncoimmunology 20120901 6
Recently, a CTLA-4 antibody and BRAF inhibitors showed survival benefits in advance melanoma treatment. The documentation of immune infiltrates in melanomas early during BRAF inhibitor therapy provides a scientific rationale for combination therapy with both treatments with possible synergistic benefits. This commentary reviews immune responses induced by BRAF inhibitors. ...[more]
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