DNA polyfluorophores for real-time multicolor tracking of dynamic biological systems.
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ABSTRACT:
SUBMITTER: Wang S
PROVIDER: S-EPMC3489938 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Publications
DNA polyfluorophores for real-time multicolor tracking of dynamic biological systems.
Wang Shenliang S Guo Jia J Ono Toshikazu T Kool Eric T ET
Angewandte Chemie (International ed. in English) 20120608 29
Dye-ing to live: Spectral limitations of common organic dyes make it difficult or impossible to visualize and follow multiple biological components in rapidly moving systems. The development of a multispectral set of improved DNA-scaffolded fluorophores is described. Their use in multicolor cellular imaging (see scheme) and in tracking of biological motions on the subsecond timescale is demonstrated. ...[more]
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