Fluorescent polymer-based post-translational differentiation and subtyping of breast cancer cells.
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SUBMITTER: Scott MD
PROVIDER: S-EPMC3490703 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
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Fluorescent polymer-based post-translational differentiation and subtyping of breast cancer cells.
Scott Michael D MD Dutta Rinku R Haldar Manas K MK Wagh Anil A Gustad Thomas R TR Law Benedict B Friesner Daniel L DL Mallik Sanku S
The Analyst 20121012 23
Herein, we report the application of synthesized fluorescent, water soluble polymers for post-translational subtyping and differentiation of breast cancer cells in vitro. The fluorescence emission spectra from these polymers were modulated differently in the presence of conditioned cell culture media from various breast cancer cells. These polymers differentiate at a post-translation level possibly due to their ability to interact with extracellular enzymes that are over-expressed in cancerous c ...[more]
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