Ontology highlight
ABSTRACT:
SUBMITTER: Slatter DA
PROVIDER: S-EPMC3491313 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Slatter David A DA Bihan Dominique G DG Jarvis Gavin E GE Stone Rachael R Pugh Nicholas N Giddu Sumana S Farndale Richard W RW
Peptides 20120423 1
Recently, the ability of polymeric collagen-like peptides to regulate cell behavior has generated great interest. A triple-helical peptide known as collagen-related peptide (CRP) contains the sequence (Gly-Pro-Hyp)(10). With Gly-Pro-Cys triplets appended to both of its termini, designated CRP(cys), chemical cross-linking using heterobifunctional reagents generates CRP(cys)-XL, a potent, widely used, polymeric agonist for platelet Glycoprotein VI, whereas non-cross-linked, monomeric CRP(cys) anta ...[more]