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The birth of the Epitranscriptome: deciphering the function of RNA modifications.

ABSTRACT: Recent studies have found methyl-6-adenosine in thousands of mammalian genes, and this modification is most pronounced near the beginning of the 3' UTR. We present a perspective on current work and new single-molecule sequencing methods for detecting RNA base modifications.

SUBMITTER: Saletore Y 

PROVIDER: S-EPMC3491402 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature

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The birth of the Epitranscriptome: deciphering the function of RNA modifications.

Saletore Yogesh Y   Meyer Kate K   Korlach Jonas J   Vilfan Igor D ID   Jaffrey Samie S   Mason Christopher E CE  

Genome biology 20121031 10

Recent studies have found methyl-6-adenosine in thousands of mammalian genes, and this modification is most pronounced near the beginning of the 3' UTR. We present a perspective on current work and new single-molecule sequencing methods for detecting RNA base modifications. ...[more]

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