The roles of the reprogramming factors Oct4, Sox2 and Klf4 in resetting the somatic cell epigenome during induced pluripotent stem cell generation.
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SUBMITTER: Schmidt R
PROVIDER: S-EPMC3491406 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
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The roles of the reprogramming factors Oct4, Sox2 and Klf4 in resetting the somatic cell epigenome during induced pluripotent stem cell generation.
Schmidt Ryan R Plath Kathrin K
Genome biology 20121022 10
Somatic cell reprogramming to induced pluripotent stem (iPS) cells by defined factors is a form of engineered reverse development carried out in vitro. Recent investigation has begun to elucidate the molecular mechanisms whereby these factors function to reset the epigenome. ...[more]
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